P2RX2 and P2RX1

Number of citations of the paper that reports this interaction (PubMedID 15313628)
42

Data Source:
HPRD (in vitro)

		P2RX2	P2RX1
Description		purinergic receptor P2X 2	purinergic receptor P2X 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Postsynapse	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Neuron Projection Membrane Raft Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Ligand-gated Ion Channel Activity Identical Protein Binding	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Cation Channel Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Cation Transmembrane Transport	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Ion Transport Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Insemination Regulation Of Blood Pressure Neuronal Action Potential Platelet Activation Response To ATP Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Ceramide Biosynthetic Process Excitatory Postsynaptic Potential Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation
Drugs		Promethazine	Promethazine
Diseases
GWAS		Body mass index ( 26426971) Fasting glucose ( 33402679)	Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		3 interacting genes: GABRR1 P2RX1 P2RX3	2 interacting genes: CYBC1 P2RX2
Entrez ID		22953	5023
HPRD ID		15984	07526
Ensembl ID		ENSG00000187848	ENSG00000108405
Uniprot IDs		Q32MC3 Q9UBL9	P51575
PDB IDs
Enriched GO Terms of Interacting Partners?
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