APOL2 and APOC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOL2	APOC2
Description		apolipoprotein L2	apolipoprotein C2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron
	Molecular Function	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding	Protein Binding Lipid Binding Phospholipase Activator Activity Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Acute-phase Response Multicellular Organism Development Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy	Positive Regulation Of Phospholipase Activity Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Cholesterol Homeostasis Negative Regulation Of Catalytic Activity Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis
Pathways			Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Copper
Diseases
GWAS		Epigenetic age acceleration in alcohol use disorder ( 31466081)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193044 20864672 19060906 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 28548082) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		33 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 EMP1 FAM209A GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 STX1A STX2 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6	28 interacting genes: APOE APOL2 BBS2 BCL2L2 CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2
Entrez ID		23780	344
HPRD ID		06263	07457
Ensembl ID		ENSG00000128335	ENSG00000234906
Uniprot IDs		A0A024R1M8 J3KQL8 Q9BQE5	A0A024R0T9 P02655
PDB IDs			1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?
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