APOC2 and IFI27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOC2	IFI27
Description		apolipoprotein C2	interferon alpha inducible protein 27
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron	Nuclear Envelope Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Lipid Binding Phospholipase Activator Activity Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity	Molecular_function Protein Binding Lamin Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Positive Regulation Of Phospholipase Activity Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Cholesterol Homeostasis Negative Regulation Of Catalytic Activity Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral Genome Replication Innate Immune Response Regulation Of Protein Export From Nucleus Defense Response To Virus Type I Interferon Signaling Pathway Protein K48-linked Ubiquitination Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways		Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport	Interferon alpha/beta signaling
Drugs		Copper
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193044 20864672 19060906 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 28548082) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		28 interacting genes: APOE APOL2 BBS2 BCL2L2 CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2	5 interacting genes: APOC2 APOC4 CCND1 CDK4 CKB
Entrez ID		344	3429
HPRD ID		07457	02479
Ensembl ID		ENSG00000234906	ENSG00000165949
Uniprot IDs		A0A024R0T9 P02655	P40305
PDB IDs		1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?
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