TRIM29 and IKBKG

Number of citations of the paper that reports this interaction (PubMedID 27695001)
62

Data Source:
BioGRID (enzymatic study)

		TRIM29	IKBKG
Description		tripartite motif containing 29	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Image
GO Annotations	Cellular Component	Lysosome Adherens Junction	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus	Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Positive Regulation Of Macroautophagy Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Establishment Of Vesicle Localization Protein-containing Complex Assembly Negative Regulation Of Neuron Death
Pathways		Interferon gamma signaling	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs			AGRO100 Tarenflurbil
Diseases
GWAS		Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)	Hemoglobin levels ( 26366553)
Interacting Genes		56 interacting genes: ACTN3 ANKS1A ATM ATP1A3 CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 HNRNPLL IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM	245 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BIRC3 BRME1 C19orf12 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IFIT5 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAPRE1 MARCHF2 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKDC PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF34 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3
Entrez ID		23650	8517
HPRD ID		10280	02217
Ensembl ID		ENSG00000137699	ENSG00000269335
Uniprot IDs		A0A024R3J1 B7Z5V5 B7Z8U9 E9PRL4 Q14134	A0A087X1B1 Q9Y6K9
PDB IDs		2CSV	2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4
Enriched GO Terms of Interacting Partners?
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