ARFIP2 and RND1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ARFIP2	RND1
Description		ADP ribosylation factor interacting protein 2	Rho family GTPase 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane	Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Actin Filament Organization Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Neuron Remodeling Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Retrograde transport at the Trans-Golgi-Network	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RND1 GTPase cycle
Drugs
Diseases
GWAS		Malaria ( 31844061)	Bipolar disorder ( 21926972)
Interacting Genes		63 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARFIP1 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF PUM3 RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	25 interacting genes: ARFIP2 ARHGAP5 CCNI COPS2 CREB3L2 EEF1A1 FRS2 FRS3 GPX8 GRB7 ID3 KRT6A MYH7 MYOM3 MYZAP NEDD1 PAIP1 PDE6D PLXNA1 PLXNB1 PLXNB2 RAI14 SHMT2 UBXN11 ZNF212
Entrez ID		23647	27289
HPRD ID		07209	12357
Ensembl ID		ENSG00000132254	ENSG00000172602
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	Q92730
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?
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