RND1 and KRT6A

		RND1	KRT6A
Description		Rho family GTPase 1	keratin 6A
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GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle	Nucleus Cytosol Membrane Keratin Filament Extracellular Exosome
	Molecular Function	GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Protein Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Actin Filament Organization Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Neuron Remodeling Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	Negative Regulation Of Cytolysis By Symbiont Of Host Cells Morphogenesis Of An Epithelium Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Cell Differentiation Wound Healing Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RND1 GTPase cycle	Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases
GWAS		Bipolar disorder ( 21926972)	Cutaneous squamous cell carcinoma ( 32041948)
Interacting Genes		25 interacting genes: ARFIP2 ARHGAP5 CCNI COPS2 CREB3L2 EEF1A1 FRS2 FRS3 GPX8 GRB7 ID3 KRT6A MYH7 MYOM3 MYZAP NEDD1 PAIP1 PDE6D PLXNA1 PLXNB1 PLXNB2 RAI14 SHMT2 UBXN11 ZNF212	50 interacting genes: BEX2 CCDC85B CCR1 DSP GEM GNL1 GOLGA2 HGS KDM1A KIFC3 KRT1 KRT13 KRT15 KRT16 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT34 KRT35 KRT36 KRT38 KRT4 KRT40 KRT5 KRT6B KRT7 LMNA MTUS2 NCALD NUP62 PRPH RND1 SGTA SMARCB1 TARBP2 TCHP TFIP11 TMBIM6 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
Entrez ID		27289	3853
HPRD ID		12357	01011
Ensembl ID		ENSG00000172602	ENSG00000205420
Uniprot IDs		Q92730	A0A0S2Z428 P02538
PDB IDs		2CLS 2REX 3Q3J	5KI0
Enriched GO Terms of Interacting Partners?
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