FPR2 and APOD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FPR2	APOD
Description		formyl peptide receptor 2	apolipoprotein D
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Cellular Response To Amyloid-beta	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Vitamin A Copper
Diseases
GWAS		Alopecia areata ( 25608926) Multiple sclerosis ( 31604244 24076602) Tourette syndrome ( 30818990)	HDL cholesterol levels ( 32203549)
Interacting Genes		6 interacting genes: APOD CAMP ERC1 FXYD6 LRRC25 SSMEM1	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		2358	347
HPRD ID		00647	00134
Ensembl ID		ENSG00000171049	ENSG00000189058
Uniprot IDs		A0A024R4P3 P25090	P05090
PDB IDs		6LW5 6OMM	2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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