FPR2 and SSMEM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FPR2	SSMEM1
Description		formyl peptide receptor 2	serine rich single-pass membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Integral Component Of Membrane
	Molecular Function	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity	Protein Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Cellular Response To Amyloid-beta
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Multiple sclerosis ( 31604244 24076602) Tourette syndrome ( 30818990)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: APOD CAMP ERC1 FXYD6 LRRC25 SSMEM1	95 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ATP6V0C BET1 BLCAP C11orf24 C1QL4 C4orf3 C5 CCL4L2 CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 LAT LEPROTL1 LNPEP MARCHF2 MCRS1 MFSD12 MFSD5 MFSD6 MIP MMD2 MS4A13 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35C2 SLC35E3 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		2358	136263
HPRD ID		00647	14060
Ensembl ID		ENSG00000171049	ENSG00000165120
Uniprot IDs		A0A024R4P3 P25090	A0A3B3ISA2 A4D1L0 Q8WWF3
PDB IDs		6LW5 6OMM
Enriched GO Terms of Interacting Partners?
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