MACF1 and CNTNAP4

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
HPRD (two hybrid)

		MACF1	CNTNAP4
Description		microtubule actin crosslinking factor 1	contactin associated protein family member 4
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane	Integral Component Of Membrane Presynaptic Membrane Cell Projection
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization	Cell Adhesion Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission, GABAergic Regulation Of Grooming Behavior
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 32499647 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Cerebrospinal T-tau levels ( 28247064) Fasting plasma glucose ( 32682390) High density lipoprotein cholesterol levels ( 33339817) Immune response to measles-mumps-rubella vaccine ( 24811271) Response to amphetamines ( 22952603) Response to haloperidol in schizophrenia ( 29503163) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Smoking status (ever vs never smokers) ( 30643258) Sphingolipid levels ( 22359512) Weight ( 34074324)
Interacting Genes		30 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC	6 interacting genes: APBA1 CASK FBXO21 MACF1 MAST3 RANBP10
Entrez ID		23499	85445
HPRD ID		09750	13079
Ensembl ID		ENSG00000127603	ENSG00000152910
Uniprot IDs		Q6ZSD7 Q9UPN3	A0A087WTA1 Q86YZ8 Q9C0A0
PDB IDs		4Z6G 5VE9 5X57	4NXQ
Enriched GO Terms of Interacting Partners?
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