MACF1 and PLXND1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
HPRD (two hybrid)

		MACF1	PLXND1
Description		microtubule actin crosslinking factor 1	plexin D1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways			Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription RND2 GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 32499647 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)	Body shape index ( 34021172) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		30 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC	8 interacting genes: H1-10 HOXB5 ISY1 MACF1 PODXL2 SEC61A1 SEMA4A TMCC1
Entrez ID		23499	23129
HPRD ID		09750	05046
Ensembl ID		ENSG00000127603	ENSG00000004399
Uniprot IDs		Q6ZSD7 Q9UPN3	Q9Y4D7
PDB IDs		4Z6G 5VE9 5X57	3H6N
Enriched GO Terms of Interacting Partners?
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