SEC11A and BCHE

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SEC11A	BCHE
Description		SEC11 homolog A, signal peptidase complex subunit	butyrylcholinesterase
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nuclear Envelope Lumen Endoplasmic Reticulum Lumen Plasma Membrane Membrane Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Amyloid-beta Binding Catalytic Activity Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Enzyme Binding Choline Binding Identical Protein Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Signal Peptide Processing	Acetylcholine Catabolic Process Learning Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Neuroblast Differentiation Choline Metabolic Process Response To Alkaloid Cocaine Metabolic Process Negative Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Folic Acid
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs			Choline Tacrine Dipivefrin Pyridostigmine Galantamine Isoflurophate Pralidoxime Malathion Donepezil Hexafluronium Demecarium Rivastigmine Edrophonium Echothiophate Ketamine Mivacurium Diethyl phosphonate Methylphosphinic Acid Butyric Acid 9-N-Phenylmethylamino-Tacrine 2-(N-morpholino)ethanesulfonic acid Ethyl dihydrogen phosphate Butyrylthiocholine Phenserine DODECANESULFONATE ION 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE (1R)-menthyl hexyl phosphonate group (1S)-menthyl hexyl phosphonate group Ethyl hydrogen diethylamidophosphate Dichlorvos Choline salicylate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Alzheimer's disease biomarkers ( 23419831) Aspirin hydrolysis (plasma) ( 23508960) Blood protein levels ( 29875488) Butyrylcholinesterase levels ( 21862451) Cardiovascular disease risk factors ( 21943158) Fast beta electroencephalogram ( 28070124) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FEV1/FVC) ( 30804560) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560)
Interacting Genes		15 interacting genes: ADAM33 AGBL1 BCHE CCL3 CCNDBP1 CEP76 CSNK2B KLHL25 LINC00052 NUPR1 OAZ2 PDE8A PDIA3 RAB27B SLC35F6	4 interacting genes: COLQ SEC11A TRIM55 TRIM63
Entrez ID		23478	590
HPRD ID		07503	01519
Ensembl ID		ENSG00000140612	ENSG00000114200
Uniprot IDs		A0A024RC78 H0YKT4 P67812	P06276
PDB IDs			1EHO 1EHQ 1KCJ 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK 2Y1K 3DJY 3DKK 3O9M 4AQD 4AXB 4B0O 4B0P 4BBZ 4BDS 4TPK 4XII 5DYT 5DYW 5DYY 5K5E 5LKR 5NN0 6EMI 6EP4 6EQP 6EQQ 6ESJ 6ESY 6EUL 6EYF 6EZ2 6F7Q 6I0B 6I0C 6I2T 6QAA 6QAB 6QAC 6QAD 6QAE 6R6V 6R6W 6RUA 6SAM 6T9P 6T9S 6XTA
Enriched GO Terms of Interacting Partners?
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