SEC11A and AGBL1

		SEC11A	AGBL1
Description		SEC11 homolog A, signal peptidase complex subunit	AGBL carboxypeptidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Metallocarboxypeptidase Activity Zinc Ion Binding Tubulin Binding
	Biological Process	Signal Peptide Processing	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)
Interacting Genes		15 interacting genes: ADAM33 AGBL1 BCHE CCL3 CCNDBP1 CEP76 CSNK2B KLHL25 LINC00052 NUPR1 OAZ2 PDE8A PDIA3 RAB27B SLC35F6	2 interacting genes: SEC11A ZNF592
Entrez ID		23478	123624
HPRD ID		07503	07115
Ensembl ID		ENSG00000140612	ENSG00000273540
Uniprot IDs		A0A024RC78 H0YKT4 P67812	Q96MI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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