NOMO1 and VWF

		NOMO1	VWF
Description		NODAL modulator 1	von Willebrand factor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding Ribosome Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein N-terminus Binding Chaperone Binding
	Biological Process	Biological_process Negative Regulation Of Nodal Signaling Pathway	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor
Drugs		Theophylline	Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa
Diseases
GWAS			Blood protein levels ( 29875488) Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 26805783 22139419 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		24 interacting genes: ATF7IP BAG6 BAIAP3 CASP4 CFB DLG4 ECT2 EXOSC10 KCNA1 MPV17L NCLN NDE1 NTAN1 PDZD3 PPIE SHBG STAT1 TOM1L1 TRIM55 TRIM63 UBQLN4 UPF2 VWF ZNF75A	22 interacting genes: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B MAP3K3 NOMO1 NUFIP2 P4HB RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		23420	7450
HPRD ID		11398	01906
Ensembl ID		ENSG00000103512	ENSG00000110799
Uniprot IDs		Q15155	P04275
PDB IDs			1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29
Enriched GO Terms of Interacting Partners?
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