PPP1R13B and APC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		PPP1R13B	APC
Description		protein phosphatase 1 regulatory subunit 13B	APC regulator of WNT signaling pathway
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane Catenin Complex Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Perinuclear Region Of Cytoplasm Wnt Signalosome
	Molecular Function	P53 Binding Protein Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding
	Biological Process	Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neuron Death	Mitotic Cytokinesis Cell Fate Specification Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Death Wnt Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Bicellular Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)	Age at first sexual intercourse ( 34211149) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Daytime nap ( 33568662) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)
Interacting Genes		72 interacting genes: ACSF3 APC ARHGAP45 BFSP2 BRCA1 C2orf42 CAPN7 CBY2 CCDC102B CCDC184 CCHCR1 CDC5L CEP57 CEP63 CGN CKS1B DEUP1 DGCR6L DIRAS1 DTNB FAM184A FAM90A1 GAS2L2 GINS4 GOLGA1 HMG20B HNRNPUL1 KHDRBS1 KHDRBS3 KIF9 KIFC3 KRT20 KRT4 LMNB1 LMNB2 LMO1 LMO3 LNX1 MATN4 MCRS1 MIPOL1 MIS18A MLH1 NAP1L2 NDC80 NEK7 NHSL2 PLEKHA5 PPFIA3 PPP1CA PPP1R18 PRKAB2 PRPH PRR35 RALBP1 RASAL3 RASSF8 SALL1 SOGA1 TCL1A TEKT4 TEX12 TEX9 TNIK TP63 TP73 TRAF1 TSG101 TSGA10 TXLNA ZGPAT ZZZ3	138 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HPCA HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAN2A1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 YWHAQ ZNF106 ZNF510
Entrez ID		23368	324
HPRD ID		07345	01439
Ensembl ID		ENSG00000088808	ENSG00000134982
Uniprot IDs		Q96KQ4	P25054 Q4LE70
PDB IDs		6HL5	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H
Enriched GO Terms of Interacting Partners?
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