APC and HNRNPM

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		APC	HNRNPM
Description		APC regulator of WNT signaling pathway	heterogeneous nuclear ribonucleoprotein M
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane Catenin Complex Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Perinuclear Region Of Cytoplasm Wnt Signalosome	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Membrane Nuclear Matrix Paraspeckles Collagen-containing Extracellular Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding	RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Mitotic Cytokinesis Cell Fate Specification Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Death Wnt Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Bicellular Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Stability Involved In Response To Oxidative Stress
Pathways		Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Daytime nap ( 33568662) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)	Coronary artery disease ( 29212778)
Interacting Genes		138 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HPCA HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAN2A1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 YWHAQ ZNF106 ZNF510	113 interacting genes: AKAP9 APC CDC5L CEACAM5 DUX4 ECPAS FXR1 FXR2 GMCL2 GSK3A GSK3B HGS HNRNPF HNRNPH1 JUN LENG8 LMO1 LMO2 LMO3 LYST MAGEA6 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PLRG1 PRRC2A RBM4 RBM4B RFX2 SMARCB1 STAT3 SUMO2 TCERG1 TEKT4 TRAF1 TSC1 TSGA10 U2AF1 UBC UBE2I WDR77 YWHAG ZNF207
Entrez ID		324	4670
HPRD ID		01439	01188
Ensembl ID		ENSG00000134982	ENSG00000099783
Uniprot IDs		P25054 Q4LE70	P52272 Q59ES8
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H	2DGV 2DH9 2DO0 2OT8
Enriched GO Terms of Interacting Partners?
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