OBSL1 and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
8

Data Source:
BioGRID (two hybrid)

		OBSL1	MCPH1
Description		obscurin like cytoskeletal adaptor 1	microcephalin 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Intercalated Disc Z Disc M Band Synapse Perinuclear Region Of Cytoplasm 3M Complex	Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity	Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Golgi Organization Regulation Of Mitotic Nuclear Division Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Retina Layer Formation Protein Localization To Golgi Apparatus Positive Regulation Of Dendrite Morphogenesis Cardiac Myofibril Assembly	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance
Pathways		Neddylation	Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		5 interacting genes: HSPB1 KCNE4 LTB4R2 MCPH1 TNS2	68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		23363	79648
HPRD ID		19306	06174
Ensembl ID		ENSG00000124006	ENSG00000147316
Uniprot IDs		O75147 Q9H8B3	Q8NEM0
PDB IDs		2CPC 2E6P 2E6Q 2LU7 2LVC 2WP3 2WWK 2WWM 3KNB 5FM5	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D
Enriched GO Terms of Interacting Partners?
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