OBSL1 and KCNE4

Number of citations of the paper that reports this interaction (PubMedID 20498229)
13

Data Source:
BioGRID (two hybrid)

		OBSL1	KCNE4
Description		obscurin like cytoskeletal adaptor 1	potassium voltage-gated channel subfamily E regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Intercalated Disc Z Disc M Band Synapse Perinuclear Region Of Cytoplasm 3M Complex	Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Golgi Organization Regulation Of Mitotic Nuclear Division Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Retina Layer Formation Protein Localization To Golgi Apparatus Positive Regulation Of Dendrite Morphogenesis Cardiac Myofibril Assembly	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Neddylation	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Coronary artery disease in type 1 diabetes ( 32077919) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Recurrent major depressive disorder x sex interaction ( 34099189) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		5 interacting genes: HSPB1 KCNE4 LTB4R2 MCPH1 TNS2	10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX
Entrez ID		23363	23704
HPRD ID		19306	09689
Ensembl ID		ENSG00000124006
Uniprot IDs		O75147 Q9H8B3	A5H1P5 Q8WWG9
PDB IDs		2CPC 2E6P 2E6Q 2LU7 2LVC 2WP3 2WWK 2WWM 3KNB 5FM5
Enriched GO Terms of Interacting Partners?
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