PACS2 and BIRC3

Number of citations of the paper that reports this interaction (PubMedID 24633224)
9

Data Source:
BioGRID (pull down)

		PACS2	BIRC3
Description		phosphofurin acidic cluster sorting protein 2	baculoviral IAP repeat containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Membrane Raft
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Apoptotic Process Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization To Phagophore Assembly Site Protein Localization To Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering	Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity
Pathways			NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		4 interacting genes: BIRC2 BIRC3 PKD2 TRAF2	42 interacting genes: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 FDX1 GLMN GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1
Entrez ID		23241	330
HPRD ID		17816	03426
Ensembl ID		ENSG00000179364	ENSG00000023445
Uniprot IDs		Q86VP3 Q8N7J0	Q13489
PDB IDs			2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?
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