TTLL12 and DNAJB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology)

		TTLL12	DNAJB1
Description		tubulin tyrosine ligase like 12	DnaJ heat shock protein family (Hsp40) member B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Spindle Midbody	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Tubulin-tyrosine Ligase Activity Protein Binding ATP Binding Tubulin Binding Histone-lysine N-methyltransferase Activity H4K20me3 Modified Histone Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Cellular Protein Modification Process Regulation Of Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Histone H4-K20 Methylation	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways		Carboxyterminal post-translational modifications of tubulin	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Molar-incisor hypomineralization ( 23918034) Monocyte count ( 32888494 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		7 interacting genes: CSNK2A2 DNAJB1 EEF1A1 EEF1A2 FAM222B PRR35 SUMO2	31 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 DNM2 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36
Entrez ID		23170	3337
HPRD ID		13782	05198
Ensembl ID		ENSG00000100304	ENSG00000132002
Uniprot IDs		A0A024R4U3 Q14166	P25685 Q6FHS4
PDB IDs			1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N
Enriched GO Terms of Interacting Partners?
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