FLNA and FURIN

Number of citations of the paper that reports this interaction (PubMedID 9412467)
54

Data Source:
HPRD (in vivo)

		FLNA	FURIN
Description		filamin A	furin, paired basic amino acid cleaving enzyme
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Z Disc Cortical Cytoskeleton Myb Complex Actin Filament Bundle Dendritic Shaft Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Apical Dendrite Postsynapse Glutamatergic Synapse	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Integral Component Of Golgi Membrane Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Protein Kinase C Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding
	Biological Process	Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Heart Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Early Endosome To Late Endosome Transport Establishment Of Protein Localization Cell-cell Junction Organization Positive Regulation Of Axon Regeneration Synapse Organization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Blastocyst Formation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Peptide Processing Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Regulation Of Cholesterol Transport Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Dibasic Protein Processing Positive Regulation Of Transforming Growth Factor Beta1 Activation Amyloid Fibril Formation
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Amyloid fiber formation
Drugs		Artenimol	Capric acid
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Age at first sexual intercourse ( 27089180 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Ischemic stroke ( 29531354) Left-handedness ( 32989287) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494)
Interacting Genes		100 interacting genes: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HHLA3 HMGB2 HNRNPD HSPA6 HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	38 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 ASH2L BACE1 CNMD COL23A1 DSG3 EDA FES FGF2 FLNA FLNC IDH2 IL1B ITM2C LRP1 MMP14 NAGPA NOTCH1 NPC1 NUCB2 PACS1 PDE4D PDGFA PELO PMCH PRB4 SERPINB8 SORCS1 SORL1 TMOD3 TNFSF13 VWF ZP3 ZP4
Entrez ID		2316	5045
HPRD ID		02060	00653
Ensembl ID		ENSG00000196924	ENSG00000140564
Uniprot IDs		P21333 Q60FE5 Q6NXF2	A0A024RC70 P09958
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1	4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7
Enriched GO Terms of Interacting Partners?
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