NFASC and SCN1B

Number of citations of the paper that reports this interaction (PubMedID 11470829)
66

Data Source:
HPRD (in vivo)

		NFASC	SCN1B
Description		neurofascin	sodium voltage-gated channel beta subunit 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Paranodal Junction Node Of Ranvier Axon Initial Segment Schwann Cell Microvillus Ficolin-1-rich Granule Membrane	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Node Of Ranvier Perikaryon
	Molecular Function	Protein Binding Protein Domain Specific Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential
	Biological Process	Cell Adhesion Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Myelination Synapse Organization Protein Localization To Plasma Membrane	Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) High myopia ( 32428537) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Regular attendance at a religious group ( 29970889)	Metabolite levels ( 23823483) Serum albumin level ( 23022100)
Interacting Genes		12 interacting genes: ABI1 ABI2 ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B
Entrez ID		23114	6324
HPRD ID		12372	02581
Ensembl ID		ENSG00000163531	ENSG00000105711
Uniprot IDs		B4DRH7 O94856	A0A1W2PR05 Q07699
PDB IDs		3P3Y 3P40	6AGF 6J8G 6J8H 6J8I 6J8J
Enriched GO Terms of Interacting Partners?
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