AKR1B1 and APLNR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		AKR1B1	APLNR
Description		aldo-keto reductase family 1 member B	apelin receptor
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytosol Plasma Membrane Bounded Cell Projection Cytoplasm Paranodal Junction Mast Cell Granule Schmidt-Lanterman Incisure Perinuclear Region Of Cytoplasm Extracellular Exosome Schwann Cell Microvillus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Protein Binding Electron Transfer Activity Cis-1,2-dihydro-1,2-dihydroxynaphthalene Dehydrogenase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Glyceraldehyde Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity Glycerol Dehydrogenase [NADP+] Activity NADP-retinol Dehydrogenase Activity	G Protein-coupled Receptor Activity Protein Binding Signaling Receptor Activity Apelin Receptor Activity
	Biological Process	Retinoid Metabolic Process Tissue Homeostasis Epithelial Cell Maturation Renal Water Homeostasis Carbohydrate Metabolic Process Sorbitol Biosynthetic Process Prostaglandin Metabolic Process C21-steroid Hormone Biosynthetic Process Response To Water Deprivation Electron Transport Chain Stress-activated Protein Kinase Signaling Cascade Regulation Of Urine Volume Norepinephrine Metabolic Process Retinol Metabolic Process Negative Regulation Of Apoptotic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Fructose Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Maternal Process Involved In Female Pregnancy Cellular Hyperosmotic Salinity Response Inner Medullary Collecting Duct Development Metanephric Collecting Duct Development Response To Thyroid Hormone Cellular Response To Methylglyoxal Cellular Response To Peptide	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping Atrioventricular Valve Development Endocardial Cushion Formation G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of Inhibitory G Protein-coupled Receptor Phosphorylation
Pathways		Pregnenolone biosynthesis Fructose biosynthesis	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Glutathione NADH Sulindac Inhibitor Idd 384 alpha-D-glucose 6-phosphate Alrestatin Fidarestat (S,R)-fidarestat Zenarestat Tolrestat N-Acetylalanine Sorbinil IDD552 Cacodylic acid Nicotinamide adenine dinucleotide phosphate Citric acid Ranirestat Pimagedine QR-333 Exisulind (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID Lidorestat {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid CP-744809 (R)-minalrestat 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE IDD594 {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid Zopolrestat
Diseases
GWAS		Blood protein levels ( 30072576 29875488) White matter growth ( 29682794)
Interacting Genes		6 interacting genes: APLNR CDC42 EFCAB11 LY6E SHBG SMAD1	8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3
Entrez ID		231	187
HPRD ID		00071	02503
Ensembl ID		ENSG00000085662	ENSG00000134817
Uniprot IDs		A0A024R7A8 P15121	B2RDH3 B3KQN4 P35414
PDB IDs		1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU 3LBO 3LD5 3LEN 3LEP 3LQG 3LQL 3LZ3 3LZ5 3M0I 3M4H 3M64 3MB9 3MC5 3ONB 3ONC 3P2V 3Q65 3Q67 3RX2 3RX3 3RX4 3S3G 3T42 3U2C 3V35 3V36 4GCA 4GQ0 4IGS 4JIR 4LAU 4LAZ 4LB3 4LB4 4LBR 4LBS 4NKC 4PR4 4PRR 4PRT 4PUU 4PUW 4Q7B 4QBX 4QR6 4QX4 4QXI 4RPQ 4XZH 4XZI 4YS1 4YU1 5HA7 5OU0 5OUJ 5OUK 6F7R 6F81 6F82 6F84 6F8O 6SYW 6T27 6T3P 6T5G 6T7Q 6TD8 6TUC 6TUF 6TXP 6XUM 6Y03 6Y1P	2LOT 2LOU 2LOV 2LOW 5VBL 6KNM
Enriched GO Terms of Interacting Partners?
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