APLNR and APLN

Number of citations of the paper that reports this interaction (PubMedID 12603839)
100

Data Source:
HPRD (in vivo)

		APLNR	APLN
Description		apelin receptor	apelin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Signaling Receptor Activity Apelin Receptor Activity	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping Atrioventricular Valve Development Endocardial Cushion Formation G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of Inhibitory G Protein-coupled Receptor Phosphorylation	Angiogenesis Regulation Of The Force Of Heart Contraction Negative Regulation Of Systemic Arterial Blood Pressure Immune Response Signal Transduction Gastrulation Lactation Positive Regulation Of Heart Rate Negative Regulation Of Gene Expression Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63
Entrez ID		187	8862
HPRD ID		02503	02246
Ensembl ID		ENSG00000134817	ENSG00000171388
Uniprot IDs		B2RDH3 B3KQN4 P35414	Q9ULZ1
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM
Enriched GO Terms of Interacting Partners?
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