NLRP1 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 11076957)
45

Data Source:
HPRD (in vivo)

		NLRP1	CASP9
Description		NLR family pyrin domain containing 1	caspase 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex	Nucleus Cytoplasm Mitochondrion Cytosol Protein-containing Complex Apoptosome
	Molecular Function	Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Self-association Cysteine-type Endopeptidase Activator Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Defense Response To Virus Pyroptosis Self Proteolysis Antiviral Innate Immune Response NLRP1 Inflammasome Complex Assembly	Kidney Development Response To Ischemia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Antibiotic Cellular Response To Dexamethasone Stimulus Leukocyte Apoptotic Process Execution Phase Of Apoptosis Regulation Of Response To DNA Damage Stimulus
Pathways		The NLRP1 inflammasome	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases
GWAS		Migraine ( 27322543)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	48 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SLIT3 SRF VIM XIAP
Entrez ID		22861	842
HPRD ID		07364	03756
Ensembl ID		ENSG00000091592	ENSG00000132906
Uniprot IDs		Q9C000	F8VVS7 P55211
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6XKK	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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