GPC5 and DCPS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GPC5	DCPS
Description		glypican 5	decapping enzyme, scavenger
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix	P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	RNA 7-methylguanosine Cap Binding Exoribonuclease Activity Protein Binding Identical Protein Binding M7G(5')pppN Diphosphatase Activity
	Biological Process	Cell Migration Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Response To Menadione Negative Regulation Of Programmed Cell Death Exonucleolytic Catabolism Of Deadenylated MRNA MRNA Cis Splicing, Via Spliceosome RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport	mRNA decay by 3' to 5' exoribonuclease
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-5'-guanylic acid 7-methyl-guanosine-5'-triphosphate-5'-guanosine 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576 29875488 28240269) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 20881960 25282103 25429064 20189936) HIV-1 viral setpoint ( 20205591) Incident coronary heart disease ( 26950853) Interleukin-6 levels ( 33517400) Lung cancer ( 20304703) Metabolite levels ( 23823483 19043545) Multiple sclerosis ( 19010793) Nephrotic syndrome (acquired) ( 21441931) Neurological blood protein biomarker levels ( 31320639) Obesity-related traits ( 23251661) Rapid automised naming of letters ( 30741946) Refractive astigmatism ( 30306274) Rheumatoid arthritis ( 30423114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tetralogy of Fallot ( 23297363) Waist circumference adjusted for body mass index ( 28552196)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252)
Interacting Genes		1 interacting genes: DCPS	10 interacting genes: CDC20 CDC27 CHST4 CSNK2A2 FZR1 GPC5 KPNA2 KPNA5 KPNA6 YWHAQ
Entrez ID		2262	28960
HPRD ID		03902	16787
Ensembl ID		ENSG00000179399	ENSG00000110063
Uniprot IDs		P78333	A0A384MTI8 Q96C86
PDB IDs			1ST0 1ST4 1XML 1XMM 3BL7 3BL9 3BLA 4QDE 4QDV 4QEB 5OSY
Enriched GO Terms of Interacting Partners?
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