FES and MAN2A2

		FES	MAN2A2
Description		FES proto-oncogene, tyrosine kinase	mannosidase alpha class 2A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Microtubule Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding	Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Metal Ion Binding
	Biological Process	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization	Mannose Metabolic Process Protein Glycosylation N-glycan Processing Protein Deglycosylation
Pathways		Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Intra-Golgi traffic Reactions specific to the complex N-glycan synthesis pathway
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Coffee consumption ( 31046077) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hypertension ( 31879980 21909115) Ischemic stroke ( 29531354) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Attention deficit hyperactivity disorder ( 18839057) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Schizophrenia ( 25056061 29483656)
Interacting Genes		50 interacting genes: ALDH1B1 APP AR BCAR1 BCR BLM CBX5 CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 FURIN GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MAN2A2 MDFI MET NEDD4 NLGN4X PDE4DIP PEX11A PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STARD5 STAT3 TERF1 TRIM28 VANGL1 ZNF117 ZNF746 ZNF775	8 interacting genes: ACAN CHD3 ELP1 ENO3 FES GIT1 LUC7L2 VIM
Entrez ID		2242	4122
HPRD ID		01814	02994
Ensembl ID		ENSG00000182511	ENSG00000196547
Uniprot IDs		A0A024RC92 P07332	P49641
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF
Enriched GO Terms of Interacting Partners?
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