TMEM218 and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM218	IFNGR2
Description		transmembrane protein 218	interferon gamma receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cilium Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding
	Biological Process		Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs			Interferon gamma-1b
Diseases
GWAS		Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		72 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR	46 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CCT8 CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 GRIK1 HCRTR1 HLCS IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24
Entrez ID		219854	3460
HPRD ID		19054	00956
Ensembl ID		ENSG00000150433	ENSG00000159128
Uniprot IDs		A2RU14	A8K881 E7EUY1 P38484
PDB IDs			5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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