RTKN2 and PACSIN1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		RTKN2	PACSIN1
Description		rhotekin 2	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Cytoplasm Endosome Cytosol Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone
	Molecular Function		Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation Hemopoiesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways			Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 19430483) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 27182965) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 23028356 24390342) Systemic lupus erythematosus ( 23273568) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		2 interacting genes: BRCA1 PACSIN1	25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		219790	29993
HPRD ID		17863	05936
Ensembl ID		ENSG00000182010	ENSG00000124507
Uniprot IDs		Q8IZC4	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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