ERCC6 and RPS24

Number of citations of the paper that reports this interaction (PubMedID 31722399)
7

Data Source:
BioGRID (pull down)

		ERCC6	RPS24
Description		ERCC excision repair 6, chromatin remodeling factor	ribosomal protein S24
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage	Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding Protein-containing Complex Binding Protein N-terminus Binding ATP-dependent Chromatin Remodeler Activity	RNA Binding Structural Constituent Of Ribosome Translation Initiation Factor Binding
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Cytoplasmic Translation RRNA Processing Translation Erythrocyte Homeostasis Ribosomal Small Subunit Biogenesis
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	California verbal learning test score ( 31596458) Diverticular disease ( 30177863) Metabolite levels ( 23823483)
Interacting Genes		117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP4 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38	10 interacting genes: DUX4 ERCC6 MUC1 OGT PAH PCBD1 PCDHA9 PNISR STK17B TAF9
Entrez ID		2074	6229
HPRD ID		00596	03877
Ensembl ID		ENSG00000225830	ENSG00000138326
Uniprot IDs		A8K4Q3 P0DP91 Q03468 Q59FF6	A0A2R8Y849 P62847
PDB IDs		4CVO 6A6I	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7K5I
Enriched GO Terms of Interacting Partners?
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