ERCC6 and SENP2

Number of citations of the paper that reports this interaction (PubMedID 31722399)
7

Data Source:
BioGRID (pull down)

		ERCC6	SENP2
Description		ERCC excision repair 6, chromatin remodeling factor	SUMO specific peptidase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding Protein-containing Complex Binding Protein N-terminus Binding ATP-dependent Chromatin Remodeler Activity	Protein Binding SUMO-specific Protease Activity SUMO-specific Endopeptidase Activity
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Protein Transport Wnt Signaling Pathway Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Fat Cell Differentiation MRNA Transport
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	SUMO is proteolytically processed
Drugs
Diseases
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)
Interacting Genes		117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP4 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38	39 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		2074	59343
HPRD ID		00596	07002
Ensembl ID		ENSG00000225830	ENSG00000163904
Uniprot IDs		A8K4Q3 P0DP91 Q03468 Q59FF6	Q9HC62
PDB IDs		4CVO 6A6I	1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?
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