Description |
AKT serine/threonine kinase 1 |
protein tyrosine phosphatase non-receptor type 1 |
Image |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- Archexin
- Enzastaurin
- Perifosine
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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- 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
- 2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid
- 5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acid
- 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
- 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
- [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
- {4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acid
- Compound 19
- 3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid
- 2-(Oxalyl-Amino)-Benzoic Acid
- {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
- Novo Nordisk a/S Compound
- N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamide
- 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
- PNU177836
- 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
- {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
- 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
- (4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid
- 4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid
- L-cysteic acid
- 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
- 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
- Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
- 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
- 2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acid
- 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
- [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
- {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
- N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamide
- 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
- ISIS 113715
- Trodusquemine
- Ertiprotafib
- 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
- [(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
- 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
- 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
- 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
- [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
- 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
- 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
- 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
- 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
- N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
- [(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
- 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
- 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
- ISOTHIAZOLIDINONE ANALOG
- 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
- p-Benzoyl-L-phenylalanine
- 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
- (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
- 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
- 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
- (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
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Diseases |
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GWAS |
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Interacting Genes |
325 interacting genes:
ACAP1
ACAT2
ADCY10
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOC1
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BUB1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDC42
CDH1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
ITSN1
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
MESD
METTL1
MIS12
MLH3
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NEDD4
NF1
NF2
NGB
NLGN3
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NSD3
OSGIN1
PAK1
PCK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
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66 interacting genes:
ACTN1
AGR3
AKT1
AQP6
ASS1
BCAR1
BCAS3
BCR
CAPN2
CASC3
CASZ1
CAV1
CCL5
CDH13
CDH2
CDK1
CLK1
CLK2
COP1
CRK
CSNK2A1
CSNK2A2
CTNNB1
DIRAS3
EGFR
ELOVL4
ESR1
FGFR1
GHR
GLRX
GRB2
GSK3B
IGF1R
INSR
IRS1
JAK2
KLK7
LAT
LRATD2
LTK
MAPK1
MRC2
NFKBIA
NTRK1
NTRK2
NTRK3
PDGFRB
PIAS1
PIGP
PIN1
RHOBTB2
RRAS2
SNAI1
SRC
STAM2
STAT3
STAT5A
STAT5B
THRSP
TIMMDC1
TMEM31
TMEM41A
TMEM86B
TRPV6
TYK2
VPS45
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Entrez ID |
207 |
5770 |
HPRD ID |
01261 |
01477 |
Ensembl ID |
ENSG00000142208
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ENSG00000196396
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Uniprot IDs |
B0LPE5
B3KVH4
P31749
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A8K3M3
B4DSN5
P18031
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PDB IDs |
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
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1A5Y
1AAX
1BZC
1BZH
1BZJ
1C83
1C84
1C85
1C86
1C87
1C88
1ECV
1EEN
1EEO
1G1F
1G1G
1G1H
1G7F
1G7G
1GFY
1I57
1JF7
1KAK
1KAV
1L8G
1LQF
1NL9
1NNY
1NO6
1NWE
1NWL
1NZ7
1OEM
1OEO
1OES
1OET
1OEU
1OEV
1ONY
1ONZ
1PA1
1PH0
1PTT
1PTU
1PTV
1PTY
1PXH
1PYN
1Q1M
1Q6J
1Q6M
1Q6N
1Q6P
1Q6S
1Q6T
1QXK
1SUG
1T48
1T49
1T4J
1WAX
1XBO
2AZR
2B07
2B4S
2BGD
2BGE
2CM2
2CM3
2CM7
2CM8
2CMA
2CMB
2CMC
2CNE
2CNF
2CNG
2CNH
2CNI
2F6F
2F6T
2F6V
2F6W
2F6Y
2F6Z
2F70
2F71
2FJM
2FJN
2H4G
2H4K
2HB1
2HNP
2HNQ
2NT7
2NTA
2QBP
2QBQ
2QBR
2QBS
2VEU
2VEV
2VEW
2VEX
2VEY
2ZMM
2ZN7
3A5J
3A5K
3CWE
3D9C
3EAX
3EB1
3EU0
3I7Z
3I80
3QKP
3QKQ
3SME
3ZMP
3ZMQ
3ZV2
4BJO
4I8N
4QAH
4QAP
4QBE
4QBW
4Y14
4ZRT
5K9V
5K9W
5KA0
5KA1
5KA2
5KA3
5KA4
5KA7
5KA8
5KA9
5KAA
5KAB
5KAC
5KAD
5QDE
5QDF
5QDG
5QDH
5QDI
5QDJ
5QDK
5QDL
5QDM
5QDN
5QDO
5QDP
5QDQ
5QDR
5QDS
5QDT
5QDU
5QDV
5QDW
5QDX
5QDY
5QDZ
5QE0
5QE1
5QE2
5QE3
5QE4
5QE5
5QE6
5QE7
5QE8
5QE9
5QEA
5QEB
5QEC
5QED
5QEE
5QEF
5QEG
5QEH
5QEI
5QEJ
5QEK
5QEL
5QEM
5QEN
5QEO
5QEP
5QEQ
5QER
5QES
5QET
5QEU
5QEV
5QEW
5QEX
5QEY
5QEZ
5QF0
5QF1
5QF2
5QF3
5QF4
5QF5
5QF6
5QF7
5QF8
5QF9
5QFA
5QFB
5QFC
5QFD
5QFE
5QFF
5QFG
5QFH
5QFI
5QFJ
5QFK
5QFL
5QFM
5QFN
5QFO
5QFP
5QFQ
5QFR
5QFS
5QFT
5QFU
5QFV
5QFW
5QFX
5QFY
5QFZ
5QG0
5QG1
5QG2
5QG3
5QG4
5QG5
5QG6
5QG7
5QG8
5QG9
5QGA
5QGB
5QGC
5QGD
5QGE
5QGF
5T19
6B8E
6B8T
6B8X
6B8Z
6B90
6B95
6BAI
6CWU
6CWV
6NTP
6OL4
6OLQ
6OLV
6OMY
6PFW
6PG0
6PGT
6PHA
6PHS
6PM8
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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