AKT1 and PSMC5

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		AKT1	PSMC5
Description		AKT serine/threonine kinase 1	proteasome 26S subunit, ATPase 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Plasma Membrane Cell-cell Junction Microtubule Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase C Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Enzyme Binding Nitric-oxide Synthase Regulator Activity GTPase Activating Protein Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Phosphatase 2A Binding 14-3-3 Protein Binding Potassium Channel Activator Activity Protein Serine Kinase Activity	Protein Binding ATP Binding Transcription Factor Binding Thyrotropin-releasing Hormone Receptor Binding Proteasome-activating Activity General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Translation Regulation Of Translation Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Activation-induced Cell Death Of T Cells Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Germ Cell Development Aging Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Carbohydrate Transport Response To Heat Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Spinal Cord Development Cell Projection Organization Cell Differentiation Protein Catabolic Process Hyaluronan Metabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Response To Food Positive Regulation Of Cellular Protein Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus NIK/NF-kappaB Signaling Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Anoikis Regulation Of MRNA Stability Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Size Negative Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Negative Regulation Of JNK Cascade Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Striated Muscle Cell Differentiation Excitatory Postsynaptic Potential Response To Growth Hormone Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Response To UV-A Response To Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Protein Kinase Activity By Protein Phosphorylation Negative Regulation Of Calcium Import Into The Mitochondrion Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Aerobic Respiration Positive Regulation Of I-kappaB Phosphorylation Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 30275531 25961943) HDL cholesterol levels ( 32203549 28334899) Neutrophil count ( 32888494) Vitamin C levels ( 33203707)
Interacting Genes		325 interacting genes: ACAP1 ACAT2 ADCY10 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF APLP2 APOC1 APOH APP APPL1 AR ARAF ARFIP2 ARNT ATXN1 AURKA BABAM1 BAD BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BUB1 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CD44 CDC37 CDC42 CDH1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CHEK1 CHUK CLASP2 CLIP3 CLK2 CNOT9 CREB1 CREBBP CSNK2A1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 ITSN1 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MATK MDM2 MDM4 MESD METTL1 MIS12 MLH3 MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCOA4 NCOR2 NEDD4 NF1 NF2 NGB NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NSD3 OSGIN1 PAK1 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 PPARGC1B PPL PPM1A PPP2CA PPP2R1A PRG2 PRKCQ PRKCZ PRKDC PSMC5 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYGO2 RAB3D RAC1 RAF1 RARA RASL10B RASSF1 RGCC RHEBL1 RNF11 RNF115 RPS6KB1 S100A14 S1PR1 SERPINB5 SETDB1 SH2B2 SH3RF1 SIRPA SIRT1 SIRT6 SKI SKP2 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS2 SOX4 SP1 SP3 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRIB3 TRIM13 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 USP4 UXS1 VEGFA VHL VIM WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1 ZNF691 ZRANB1	81 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS FXR1 GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 LAMC1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 OGT PDC PDCL PLEKHO1 PPARD PRKN PSMC1 PSMC2 PSMC3 PSMC4 PSMC6 PSMD11 PSMD12 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TPM3 TRIP11 UBE3C UBLCP1 USP4 VDR VIM
Entrez ID		207	5705
HPRD ID		01261	03400
Ensembl ID		ENSG00000142208	ENSG00000087191
Uniprot IDs		B0LPE5 B3KVH4 P31749	A0A140VJS3 P62195
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X	2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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