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ERCC2 and GTF2H2
Number of citations of the paper that reports this interaction (PubMedID
9771713
)
79
Data Source:
HPRD
(in vivo, in vitro)
ERCC2
GTF2H2
Description
ERCC excision repair 2, TFIIH core complex helicase subunit
general transcription factor IIH subunit 2
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Cytoplasm
Spindle
Cytosol
CAK-ERCC2 Complex
MMXD Complex
Core TFIIH Complex Portion Of Holo TFIIH Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Nuclear Speck
Molecular Function
DNA Helicase Activity
Damaged DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
ATP Hydrolysis Activity
Protein-macromolecule Adaptor Activity
5'-3' DNA Helicase Activity
Metal Ion Binding
Protein N-terminus Binding
4 Iron, 4 Sulfur Cluster Binding
Protein Binding
Zinc Ion Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Protein N-terminus Binding
Biological Process
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nucleotide-excision Repair, DNA Duplex Unwinding
Response To Hypoxia
In Utero Embryonic Development
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Apoptotic Process
Response To Oxidative Stress
Chromosome Segregation
Aging
Cell Population Proliferation
Response To UV
UV Protection
Post-embryonic Development
Spinal Cord Development
Extracellular Matrix Organization
Bone Mineralization
Central Nervous System Myelin Formation
Nucleotide-excision Repair, DNA Incision
Multicellular Organism Growth
Hair Cell Differentiation
Embryonic Cleavage
Erythrocyte Maturation
Positive Regulation Of DNA Binding
Positive Regulation Of Mitotic Recombination
Embryonic Organ Development
Hair Follicle Maturation
Hematopoietic Stem Cell Differentiation
Regulation Of Mitotic Cell Cycle Phase Transition
G Protein-coupled Receptor Internalization
Nucleotide-excision Repair
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Response To UV
Positive Regulation Of DNA Helicase Activity
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
Cytosolic iron-sulfur cluster assembly
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Lung Cancer (DNA repair capacity) (
23108145
)
Sleep (1/2-day periodicity) (
33075057
)
Interacting Genes
17 interacting genes:
AR
CDK1
CDK7
ERCC3
ERCC5
GTF2E1
GTF2H1
GTF2H2
GTF2H2C_2
GTF2H3
HERC5
MNAT1
MTDH
RAD51
RAD52
TP53
TRIM25
16 interacting genes:
AR
CDK7
CWC27
CYP26B1
DNMT3L
ERCC2
ERCC3
ERCC8
ERRFI1
GTF2E1
GTF2H1
GTF2H3
GTF2H4
GTF2H5
MNAT1
SRA1
Entrez ID
2068
2966
HPRD ID
00530
03450
Ensembl ID
ENSG00000104884
ENSG00000145736
Uniprot IDs
P18074
Q13888
PDB IDs
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
6TUN
1Z60
5IVW
5IY6
5IY7
5IY8
5IY9
5O85
5OF4
6NMI
6O9L
6O9M
6RO4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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