ERCC2

Description		ERCC excision repair 2, TFIIH core complex helicase subunit
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol CAK-ERCC2 Complex MMXD Complex
	Molecular Function	DNA Helicase Activity Damaged DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity 5'-3' DNA Helicase Activity Metal Ion Binding Protein N-terminus Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleotide-excision Repair, DNA Duplex Unwinding Response To Hypoxia In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Apoptotic Process Response To Oxidative Stress Chromosome Segregation Aging Cell Population Proliferation Response To UV UV Protection Post-embryonic Development Spinal Cord Development Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation Nucleotide-excision Repair, DNA Incision Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Erythrocyte Maturation Positive Regulation Of DNA Binding Positive Regulation Of Mitotic Recombination Embryonic Organ Development Hair Follicle Maturation Hematopoietic Stem Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript Cytosolic iron-sulfur cluster assembly NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Lung Cancer (DNA repair capacity) ( 23108145) Sleep (1/2-day periodicity) ( 33075057)
Interacting Genes		17 interacting genes: AR CDK1 CDK7 ERCC3 ERCC5 GTF2E1 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 MNAT1 MTDH RAD51 RAD52 TP53 TRIM25
Entrez ID		2068
HPRD ID		00530
Ensembl ID		ENSG00000104884
Uniprot IDs		P18074
PDB IDs		5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 6TUN
Enriched GO Terms of Interacting Partners?
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