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EP300 and RORA
Number of citations of the paper that reports this interaction (PubMedID
9862959
)
28
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
EP300
RORA
Description
E1A binding protein p300
RAR related orphan receptor A
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytosol
Protein-DNA Complex
Chromatin
Nucleus
Nucleoplasm
Molecular Function
DNA-binding Transcription Activator Activity
Transcription Coregulator Binding
Transcription Coactivator Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Zinc Ion Binding
H3 Histone Acetyltransferase Activity
H4 Histone Acetyltransferase Activity
Acetyltransferase Activity
Acyltransferase Activity
Nuclear Receptor Binding
Chromatin DNA Binding
Peptide N-acetyltransferase Activity
Tau Protein Binding
Androgen Receptor Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide 2-hydroxyisobutyryltransferase Activity
Histone Lactyltransferase Activity
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
DNA-binding Transcription Factor Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Beta-catenin Binding
Oxysterol Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Ligand-activated Transcription Factor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Glycolytic Process
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Cell Cycle
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Animal Organ Morphogenesis
Regulation Of Autophagy
Macrophage Derived Foam Cell Differentiation
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
Histone Acetylation
N-terminal Peptidyl-lysine Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Positive Regulation Of Protein Binding
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Swimming
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Peptidyl-lysine Propionylation
Regulation Of Tubulin Deacetylation
Histone H3-K56 Acetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Angiogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Glucose Metabolic Process
Regulation Of Steroid Metabolic Process
Cerebellar Purkinje Cell Differentiation
Cerebellar Granule Cell Precursor Proliferation
Intracellular Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
Cellular Response To Sterol
Cholesterol Homeostasis
Muscle Cell Differentiation
Positive Regulation Of Circadian Rhythm
Regulation Of Macrophage Activation
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
CGMP Metabolic Process
Negative Regulation Of Inflammatory Response
Triglyceride Homeostasis
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
T-helper 17 Cell Differentiation
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
STAT3 nuclear events downstream of ALK signaling
Heme signaling
RORA activates gene expression
PPARA activates gene expression
Nuclear Receptor transcription pathway
Circadian Clock
SUMOylation of intracellular receptors
Interleukin-4 and Interleukin-13 signaling
Heme signaling
Drugs
Cholesterol sulfate
Cholesterol
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
28991256
25056061
29483656
)
Type 2 diabetes (
30297969
)
Adult asthma (
30787307
)
Adult body size (
32376654
)
Alanine aminotransferase levels (
33547301
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31361310
31959851
30929738
34103634
20860503
27182965
32296059
31619474
29273806
)
Asthma (adult onset) (
30929738
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma (moderate or severe) (
30552067
)
Asthma (time to onset) (
27130862
)
Asthma onset (childhood vs adult) (
30929738
)
Birth weight (
31043758
)
Blood protein levels (
28240269
)
Blood urea nitrogen levels (
31152163
29403010
)
Body mass index (
28892062
)
Body shape index (
34021172
)
Breast cancer (prognosis) (
23319801
)
C-reactive protein levels (
30388399
21300955
)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or total cholesterol levels (pleiotropy) (
27286809
)
Caffeine consumption from coffee or tea (
33287642
)
Caffeine consumption from tea (
33287642
)
Cataracts (
34127677
)
Cerebrospinal fluid beta-site APP cleaving enzyme levels (
29751835
)
Chronic central serous retinopathy (
30073298
)
Depression (quantitative trait) (
20800221
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Gamma glutamyl transferase levels (
22010049
)
Glaucoma (primary open-angle) (
33627673
)
Height (
31562340
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
High density lipoprotein cholesterol levels (
31211820
)
High light scatter reticulocyte count (
32888494
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Keratoconus (
33649486
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
22001757
)
Male-pattern baldness (
28196072
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (glucocorticoids) (
31015401
)
Menarche (age at onset) (
21102462
23599027
25231870
)
Multiple sclerosis (
31604244
)
Neuropathic pain in head and neck cancer (
29884837
)
Nickel levels (
26025379
)
Offspring birth weight (
31043758
)
Pulmonary function decline (
22424883
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Response to citalopram treatment (
19846067
)
Reticulocyte count (
32888494
)
Schizophrenia (
23212062
)
Subcutaneous adipose tissue (
22589738
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
Triglyceride levels (
32203549
32154731
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
382 interacting genes:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
AUTS2
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDC25A
CDK1
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLIC2
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EEF2
EGR1
EID1
EID2
ELF3
ELK1
ELL
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KDM2A
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCHR1
MCL1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MELTF
MGMT
MITF
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR3C1
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRG4
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RBX1
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SDC4
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIRT1
SIRT2
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNIP1
SNRPA
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF106
ZNF148
ZNF76
ZRANB2
23 interacting genes:
BHLHE41
COPS5
CSNK1E
EP300
GFAP
HIF1A
LMO3
LRIF1
MED1
MYOD1
NCOA1
NCOA2
NME1
NME2
NR0B1
NSD1
PNRC1
PNRC2
PROX1
PSMC5
SMARCD3
SP1
ZXDC
Entrez ID
2033
6095
HPRD ID
04078
02896
Ensembl ID
ENSG00000100393
ENSG00000069667
Uniprot IDs
Q09472
Q7Z6C1
A0A0C4DFP5
A0A0C4DG53
P35398
PDB IDs
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
6V8B
6V8K
6V8N
6V90
1N83
1S0X
4S15
Enriched GO Terms of Interacting Partners
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