EP300 and PAX6

Number of citations of the paper that reports this interaction (PubMedID 10506141)
31

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		EP300	PAX6
Description		E1A binding protein p300	paired box 6
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Activator Activity Transcription Coregulator Binding Transcription Coactivator Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Zinc Ion Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Acetyltransferase Activity Acyltransferase Activity Nuclear Receptor Binding Chromatin DNA Binding Peptide N-acetyltransferase Activity Tau Protein Binding Androgen Receptor Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptide-lysine-N-acetyltransferase Activity Protein Propionyltransferase Activity Pre-mRNA Intronic Binding STAT Family Protein Binding Peptide 2-hydroxyisobutyryltransferase Activity Histone Lactyltransferase Activity Peptide Butyryltransferase Activity Histone Crotonyltransferase Activity Histone Butyryltransferase Activity DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Co-SMAD Binding R-SMAD Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Somitogenesis Thigmotaxis Behavioral Defense Response Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Glycolytic Process Protein Acetylation Internal Protein Amino Acid Acetylation Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cell Cycle Nervous System Development Heart Development Skeletal Muscle Tissue Development Learning Or Memory Circadian Rhythm Animal Organ Morphogenesis Regulation Of Autophagy Macrophage Derived Foam Cell Differentiation Regulation Of Mitochondrion Organization Positive Regulation Of Neuron Projection Development Histone Acetylation N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation B Cell Differentiation Platelet Formation Lung Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Positive Regulation Of Protein Binding Cellular Response To UV Multicellular Organism Growth Megakaryocyte Development Swimming Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Face Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Peptidyl-lysine Propionylation Regulation Of Tubulin Deacetylation Histone H3-K56 Acetylation Peptidyl-lysine Crotonylation Peptidyl-lysine Butyrylation Regulation Of Cellular Response To Heat Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Blood Vessel Development Eye Development Cell Fate Determination Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Axon Guidance Central Nervous System Development Salivary Gland Morphogenesis Visual Perception Response To Wounding Regulation Of Asymmetric Cell Division Animal Organ Morphogenesis Dorsal/ventral Axis Specification Gene Expression Positive Regulation Of Gene Expression Ventral Spinal Cord Development Oligodendrocyte Cell Fate Specification Cerebral Cortex Regionalization Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain-midbrain Boundary Formation Pituitary Gland Development Habenula Development Signal Transduction Involved In Regulation Of Gene Expression Keratinocyte Differentiation Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Lacrimal Gland Development Protein Localization To Organelle Eye Photoreceptor Cell Development Glucose Homeostasis Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Embryonic Camera-type Eye Morphogenesis Neuron Fate Commitment Astrocyte Differentiation Anatomical Structure Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Core Promoter Binding Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation STAT3 nuclear events downstream of ALK signaling Heme signaling	Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) General risk tolerance (MTAG) ( 30643258) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30297969)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Body mass index ( 22344219 28892062) Depression ( 29700475) Diastolic blood pressure ( 27841878) Feeling worry ( 29500382) General factor of neuroticism ( 30867560) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Neurociticism ( 29500382) Optic disc area ( 28073927) Refractive error ( 32231278) Systolic blood pressure ( 27841878)
Interacting Genes		382 interacting genes: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALKBH4 ALX1 APEX1 AR ARHGDIA ARNT ARNTL ARSF ASCL1 ASH2L ATF4 ATF5 ATR AUTS2 BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDC25A CDK1 CDK2 CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLIC2 CLOCK CNOT4 COPS2 COPS6 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 DUX4 E2F1 E2F5 EEF1A1 EEF2 EGR1 EID1 EID2 ELF3 ELK1 ELL EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GCKR GLUL GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B H1-1 H1-3 H2AC20 H2AC21 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 H4C9 HAND2 HBP1 HDAC1 HDAC3 HDAC6 HEMGN HERC1 HIF1A HMGB1 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P ILF2 ILF3 IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KDM2A KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCHR1 MCL1 MCM2 MCM3 MCM3AP MCM4 MCM5 MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MELTF MGMT MITF MN1 MORF4L1 MPG MRE11 MSH6 MSTO1 MTOR MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR1I2 NR2F2 NR3C1 NR4A1 NUP98 NUPR1 OLIG2 ORC2 PAK2 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POLI POU3F2 PPARA PPARD PPARG PPP2R5C PRG4 PRKCA PRKCB PRKCD PRKDC PRMT1 PROX1 PTMA RACK1 RAD23A RAD50 RAN RB1 RBM14 RBX1 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 RUVBL2 SATB1 SAV1 SDC4 SELENOP SENP3 SERTAD1 SET SETD1A SIRT1 SIRT2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNRPA SNW1 SOX9 SP1 SP3 SPHK1 SPIB SREBF1 SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUMO2 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBC UBE2D1 UBE2I UBQLN1 UBTF USF2 VPS18 WDR59 WDR82 XRCC6 YWHAZ YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB49 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF106 ZNF148 ZNF76 ZRANB2	136 interacting genes: ACOT12 AP1M1 ARIH2 ATP6V0D2 ATP6V1C2 BANP BCL2L15 C1orf109 C2CD6 CCDC103 CCDC6 CCL26 CDK3 CDX2 CGGBP1 CHAF1A CIB3 CINP CKS1B CREBBP CSNK2A1 CSTF3 CTNNA3 CXorf38 DHPS DIAPH1 DLG1 DYNLL1 EAF1 EFHC1 EIF1AD EN1 EP300 ESRRG FAM50B GAS2L2 GCM2 GEMIN2 GPANK1 GRHL2 HGS HIPK2 HIVEP2 HMBOX1 HMGB3 HNRNPC HOMER3 HOXA1 HOXB1 HOXC8 HOXC9 INPP5D IPO13 KANK2 KCTD7 KRTAP9-3 KRTAP9-8 LARP4 LHX2 LNPK LONRF1 LXN LYSMD1 MAFG MAPRE1 MFAP1 MID1 MIPOL1 MISP MITF MORN3 MPPED2 MRPL53 NCDN NFKBID NFYC NGLY1 NKIRAS2 PATJ PBX1 PDE4C PICK1 PIN1 PKNOX1 POLR3C POLR3GL PPIL4 PRKAG1 PROX1 PSORS1C2 QRICH1 RAG1 RANBP3 RAX RB1 RCN1 RGS3 RNF111 SAE1 SEC14L4 SET SHANK3 SIGLEC6 SIX3 SLAMF1 SLC12A8 SMARCA4 SOX10 SOX3 SPDYC SPG21 SRSF11 STAC SUMO1 TBP TCP11L1 THOC1 TLK1 TLK2 TRAPPC6A TRIM11 TRIP10 TRMT112 UBE2F UBE2K UBE3A UBXN2B UBXN7 USHBP1 VCX2 VSX2 WASHC3 WT1 ZBED1 ZNF124 ZNF410
Entrez ID		2033	5080
HPRD ID		04078	06167
Ensembl ID		ENSG00000100393	ENSG00000007372
Uniprot IDs		Q09472 Q7Z6C1	A0A1W2PRA8 D1KF47 F1T0F8 P26367 Q66SS1
PDB IDs		1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5KJ2 5LKT 5LKU 5LKX 5LKZ 5LPK 5LPM 5NU5 5XZC 6DS6 6FGN 6FGS 6GYR 6GYT 6K4N 6PF1 6PGU 6V8B 6V8K 6V8N 6V90	2CUE 6PAX
Enriched GO Terms of Interacting Partners?
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