EIF4A1 and WDR77

Number of citations of the paper that reports this interaction (PubMedID 33020149)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EIF4A1	WDR77
Description		eukaryotic translation initiation factor 4A1	WD repeat domain 77
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATP Hydrolysis Activity	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity
	Biological Process	Cytoplasmic Translational Initiation	Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	snRNP Assembly RMTs methylate histone arginines
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 MYH10 OGT PAIP1 PDCD4 PLPPR4 PRMT1 PRMT5 SUMO2 TNKS UCHL5 UPF2 WDR77	47 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PITRM1 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		1973	79084
HPRD ID		04030	14387
Ensembl ID		ENSG00000161960	ENSG00000116455
Uniprot IDs		P60842	A0A024R0H7 Q9BQA1
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P
Enriched GO Terms of Interacting Partners?
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