EIF4A1 and PDCD4

Number of citations of the paper that reports this interaction (PubMedID 33020149)
0

Data Source:
BioGRID (pull down)

		EIF4A1	PDCD4
Description		eukaryotic translation initiation factor 4A1	programmed cell death 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATP Hydrolysis Activity	RNA Binding Protein Binding
	Biological Process	Cytoplasmic Translational Initiation	Apoptotic Process Cell Aging BMP Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Fish- and plant-related diet ( 32066663)
Interacting Genes		18 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 MYH10 OGT PAIP1 PDCD4 PLPPR4 PRMT1 PRMT5 SUMO2 TNKS UCHL5 UPF2 WDR77	21 interacting genes: APOE BTRC CSNK2A1 EIF4A1 EIF4A2 EIF4A3 EIF4G1 IBTK LRRK1 LYN OGT PRMT5 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2 WDR77
Entrez ID		1973	27250
HPRD ID		04030	10549
Ensembl ID		ENSG00000161960	ENSG00000150593
Uniprot IDs		P60842	B4DKX4 Q53EL6
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?
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