EEF1G and HDAC5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		EEF1G	HDAC5
Description		eukaryotic translation elongation factor 1 gamma	histone deacetylase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Translation Elongation Factor Activity Protein Binding Cadherin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Translational Elongation Glutathione Metabolic Process Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation
Pathways		Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Belinostat Panobinostat
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 33263727 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Mean platelet volume ( 32888494)
Interacting Genes		97 interacting genes: ABCC9 ADAP2 AKT1 ANKRD28 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DLG4 DRD3 DYSF ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B ENOX1 FADS1 FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LINC01554 LZTS1 MBD1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 OGT PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SFRP2 SKIL SLC22A2 SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	69 interacting genes: ADGRB2 ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 GOSR2 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 PSME3 RFXANK RUNX3 SFN SGCA SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SPARC ST3GAL3 SUV39H1 TAB2 UBC UBE2I UTP18 VAT1 YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		1937	10014
HPRD ID		11745	09246
Ensembl ID		ENSG00000254772	ENSG00000108840
Uniprot IDs		P26641 Q53YD7	Q9UQL6
PDB IDs		1PBU 5DQS 5JPO	5UWI
Enriched GO Terms of Interacting Partners?
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