DYNC1H1 and ATP2B3

		DYNC1H1	ATP2B3
Description		dynein cytoplasmic 1 heavy chain 1	ATPase plasma membrane Ca2+ transporting 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Extracellular Vesicle Parallel Fiber
	Molecular Function	RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Cation Transmembrane Transporter Activity PDZ Domain Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Cellular Calcium Ion Homeostasis Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Halothane Desflurane
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		29 interacting genes: ASB7 ATP2B3 BRCA1 COX20 DISC1 DUX4 DYNLL1 ECSIT EGFR KATNA1 KATNB1 LINC01554 LMO4 MRE11 MTNR1B NDEL1 PAFAH1B1 PPP2R5C PRKCD PSMB9 RHBDD2 SMAD2 SORBS2 SUMO2 TENT5A TNIK YWHAG YWHAQ ZBTB42	2 interacting genes: DYNC1H1 HTR2C
Entrez ID		1778	492
HPRD ID		02524	02057
Ensembl ID		ENSG00000197102	ENSG00000067842
Uniprot IDs		Q14204	Q16720
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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