DNAH5 and TRIO

		DNAH5	TRIO
Description		dynein axonemal heavy chain 5	trio Rho guanine nucleotide exchange factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Microtubule Axoneme Dynein Complex Motile Cilium Outer Dynein Arm 9+2 Motile Cilium	Cytosol Cell Projection
	Molecular Function	ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Central Nervous System Development Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Coffee consumption ( 29367735) Cognitive function in longevity ( 33607172) Corneal astigmatism ( 23322567) Emphysema imaging phenotypes ( 26030696) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) IgE grass sensitization ( 22036096) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Subclinical atherosclerosis traits (other) ( 17903303) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689) Visceral fat ( 22589738)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		14 interacting genes: CDH6 CKB CTNND2 DAP LARGE1 MARCHF6 MICAL1 MTDH MVP MYO10 RAN RBFOX2 TLE1 TRIO	17 interacting genes: BLMH CDC42 CDC5L DAP DISC1 DNAH5 EXOC1 FLNA ITSN2 LIMS1 MARCHF6 NIPBL PRMT7 PTK2 PTPRF RAC1 RHOA
Entrez ID		1767	7204
HPRD ID		04514	03537
Ensembl ID		ENSG00000039139	ENSG00000038382
Uniprot IDs		Q8TE73	O75962
PDB IDs			1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
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