DDB1 and SUPT3H

Number of citations of the paper that reports this interaction (PubMedID 11564863)
166

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		DDB1	SUPT3H
Description		damage specific DNA binding protein 1	SPT3 homolog, SAGA and STAGA complex component
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding	Transcription Coactivator Activity Protein Heterodimerization Activity
	Biological Process	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Histone H2A Monoubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Biological Process Involved In Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Histone Deubiquitination Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	HATs acetylate histones
Drugs
Diseases
GWAS			ADAMTS13 activity ( 25934476) Attention deficit hyperactivity disorder ( 18839057) Chin dimples ( 27182965) Estimated glomerular filtration rate ( 31152163) facial morphology traits (multivariate analysis) ( 27193062) Glaucoma ( 31959993) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 25429064 19893584 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Hip minimal joint space width ( 27701424) Intraocular pressure ( 31959993 30054594) Large artery stroke ( 24262325) Lumbar spine bone mineral density ( 22504420) Lymphocyte counts ( 32888494) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Nose morphology ( 29921221) Nose size ( 27182965) Obesity-related traits ( 23251661) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis ( 22763110) Osteoarthritis of the hand ( 28855172) Osteoarthritis of the hip or knee ( 30664745) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33547301) Stroke (ischemic) ( 22941190) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		47 interacting genes: ABL1 BRAP CCNK CDK12 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 GPS1 GSPT1 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MUS81 PIN1 PTEN RASSF1 SALL2 SHANK3 SIN3A SIRT7 SKP2 STAT1 SUPT3H SUV39H1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZNF277	5 interacting genes: DDB1 H3-4 MYC PYGO2 TCF3
Entrez ID		1642	8464
HPRD ID		10952	04254
Ensembl ID		ENSG00000167986	ENSG00000196284
Uniprot IDs		Q16531	A0A024RD67 B4E1H0 O75486
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9
Enriched GO Terms of Interacting Partners?
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