CYBB and NCF4

Number of citations of the paper that reports this interaction (PubMedID 11893732)
98

Data Source:
HPRD (in vivo)

		CYBB	NCF4
Description		cytochrome b-245 beta chain	neutrophil cytosolic factor 4
Image
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Cytoplasm Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding
	Biological Process	Superoxide Metabolic Process Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Electron Transport Chain Positive Regulation Of Tumor Necrosis Factor Production Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Angiogenesis Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Phagocytosis Superoxide Anion Generation Respiratory Burst Regulation Of Catalytic Activity
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		8 interacting genes: ACTG1 CYBA CYBC1 DYNLT3 IQGAP1 NCF2 NCF4 RAC1	10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		1536	4689
HPRD ID		02382	03289
Ensembl ID		ENSG00000165168	ENSG00000100365
Uniprot IDs		A0A0S2Z3S6 P04839	A0A494BZS1 Q15080
PDB IDs		3A1F	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?
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