NCF4 and NCF2

Number of citations of the paper that reports this interaction (PubMedID 12813044)
149

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NCF4	NCF2
Description		neutrophil cytosolic factor 4	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex	Acrosomal Vesicle Cytosol Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Phagocytosis Superoxide Anion Generation Respiratory Burst Regulation Of Catalytic Activity	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Superoxide Anion Generation Innate Immune Response Respiratory Burst Regulation Of Catalytic Activity
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 33272962 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6	15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		4689	4688
HPRD ID		03289	01991
Ensembl ID		ENSG00000100365	ENSG00000116701
Uniprot IDs		A0A494BZS1 Q15080	A0A0S2Z457 P19878
PDB IDs		1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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