CYBA and NCF2

Number of citations of the paper that reports this interaction (PubMedID 11893732)
98

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		CYBA	NCF2
Description		cytochrome b-245 alpha chain	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Acrosomal Vesicle Cytosol Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Xenobiotic Stimulus Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Cell Growth Response To Nutrient Levels Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To L-glutamine	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Superoxide Anion Generation Innate Immune Response Respiratory Burst Regulation Of Catalytic Activity
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases
GWAS		Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)	Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 33272962 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		1535	4688
HPRD ID		01989	01991
Ensembl ID		ENSG00000051523	ENSG00000116701
Uniprot IDs		B4DT46 H3BNP7 P13498	A0A0S2Z457 P19878
PDB IDs		1WLP	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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