COMMD1 and TCEAL8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COMMD1	TCEAL8
Description		copper metabolism domain containing 1	transcription elongation factor A like 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Nucleus
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding WW Domain Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways		Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		34 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC HMGB2 KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT WDPCP XIAP	5 interacting genes: APP CCDC24 CD209 COMMD1 GRB2
Entrez ID		150684	90843
HPRD ID		06253	06656
Ensembl ID		ENSG00000173163	ENSG00000180964
Uniprot IDs		Q8N668	Q8IYN2
PDB IDs		2H2M
Enriched GO Terms of Interacting Partners?
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