COMMD1 and CUL2

Number of citations of the paper that reports this interaction (PubMedID 17183367)
115

Data Source:
HPRD (in vitro)

		COMMD1	CUL2
Description		copper metabolism domain containing 1	cullin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		34 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC HMGB2 KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT WDPCP XIAP	35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B
Entrez ID		150684	8453
HPRD ID		06253	06786
Ensembl ID		ENSG00000173163	ENSG00000108094
Uniprot IDs		Q8N668	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		2H2M	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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