CSNK1A1 and UVRAG

Number of citations of the paper that reports this interaction (PubMedID 30686098)
21

Data Source:
BioGRID (pull down, enzymatic study)

		CSNK1A1	UVRAG
Description		casein kinase 1 alpha 1	UV radiation resistance associated
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Centrosome Cytosol Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Cytoplasm Lysosome Endosome Early Endosome Late Endosome Endoplasmic Reticulum Centrosome Midbody Phagocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Viral Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Maturation of nucleoprotein	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		Fostamatinib
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Stroke ( 32693751) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1	8 interacting genes: CSNK1A1 MTOR OS9 VPS11 VPS16 VPS18 VPS33B ZRANB1
Entrez ID		1452	7405
HPRD ID		02739	03929
Ensembl ID		ENSG00000113712	ENSG00000198382
Uniprot IDs		B4DER9 P48729 Q6PJ06	Q9P2Y5
PDB IDs		5FQD 6GZD	7BL1
Enriched GO Terms of Interacting Partners?
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