CRY1 and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 10428031)
496

Data Source:
HPRD (in vivo)

		CRY1	TIMELESS
Description		cryptochrome circadian regulator 1	timeless circadian regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Nuclear Receptor Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis DNA Damage Induced Protein Phosphorylation Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways		Circadian Clock	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)	Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: ARIH1 ARNTL BHLHE41 CBLB CLOCK CSNK1E DELEC1 FBXL3 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 UNG USP2 USP7	9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		1407	8914
HPRD ID		09050	04864
Ensembl ID		ENSG00000008405	ENSG00000111602
Uniprot IDs		A2I2P0 Q16526	Q9UNS1
PDB IDs			4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ
Enriched GO Terms of Interacting Partners?
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