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CRY1 and GRN
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
CRY1
GRN
Description
cryptochrome circadian regulator 1
granulin precursor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
DNA Binding
Double-stranded DNA Binding
Deoxyribodipyrimidine Photo-lyase Activity
DNA (6-4) Photolyase Activity
Protein Binding
Blue Light Photoreceptor Activity
Nuclear Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Histone Deacetylase Binding
E-box Binding
FAD Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
DNA Damage Induced Protein Phosphorylation
Circadian Rhythm
Response To Light Stimulus
Blue Light Signaling Pathway
Response To Activity
Protein-chromophore Linkage
Lipid Storage
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Glucagon
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Gluconeogenesis
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Glucocorticoid Secretion
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Circadian Clock
Neutrophil degranulation
Drugs
Diseases
GWAS
Morning person (
30696823
)
Suicide attempt severity in mood disorders (
33783297
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
27 interacting genes:
ARIH1
ARNTL
BHLHE41
CBLB
CLOCK
CSNK1E
DELEC1
FBXL3
GRN
KRTAP4-12
LTBP4
MDFI
NPAS2
NR1D2
PER1
PER2
PER3
PLSCR1
PPP2R1B
PPP2R5D
PPP2R5E
SNRPD3
TIMELESS
TRAF2
UNG
USP2
USP7
81 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MBD1
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SHANK3
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
1407
2896
HPRD ID
09050
00733
Ensembl ID
ENSG00000008405
ENSG00000030582
Uniprot IDs
A2I2P0
Q16526
P28799
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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